For Veterinary Use Only
Proven Science. Proven Results.
Synamid® is a non-resorbable, injectbale, hydrophyllic gel for intra-articular administration for the management of osteoarthritis in dogs.
- The new generation joint treatment
- 2.5% cross-linked polyacrylamide hydrogel
- Long-lasting - non-absorbable
- 82.5% successful resolution of joint lameness out to 24 month
- Integrates into the joint tissue providing shock absorption to the joint
- Safe, biocompatible, non-toxic and neuro-innocuous
*Federal law restricts this device to sale by or on the order of a licensed veterinarian and it must be used under the supervision of a licensed veterinarian for the application of intra-articular administration. Orders will only be shipped to licensed Veterinary Practices.
Synamid® is a non-resorbable, injectable, transparent, hydrophilic gel, for intra-articular administration in dogs only.
Synamid® consists of a backbone of cross-linked polyacrylamide, with water molecules loosely bound to the polyer matrix. Nominal proportions of the Synamid® gel are 2.5% cross-linked polycrylamide and 97.5% non-pyrogenic water for injection, Synamid® is biocompatible and non-biodegradable and is sterilized by moist heat.
Synamid® is supplied in a pre-filled, sterile, 1 mL syringe sealed with a luer lock fitting. It is intended to be injected with a sterile 21-23-gauge hypodermic needle.
Synamid® is for intra-articular use only and must be administered by a qualified veterinarian familiar with the procedure in the intended species. Animals may be sedated or anaesthetized to minimize stress and discomfort.
As with any intra-articular procedure, a Synamid® injection carries a risk of infection. Standard precautions and strict aseptic conditions must be followed at all times.
A 21-23G needle is placed intra-articularly. Synovial fluid should be observed. Care should be taken to avoid unnecessary damage of the intra-articular tissue, as this may result in diffuse swelling lasting for 24 to 48 hours. Remove the protective tip cap from the Synamid® syringe. Attach the syringe firmly into the Luer lock socket on the needle. Make sure the syringe is correctly mounted. If more than 1 mL of Synamid® is required for the joint, detach the empty Synamid® syringe from the hypodermic needle and repeat the process until the required dose is delivered.
The following dosage recommendations have been made, based on observed clinical responses to administration:
Shoulder, elbow, hip and stifle
- Size of Dog – < 20kg / Dose to be administered – 0.5 mL
- Size of Dog – > 20kg / Dose to be administered – 1 mL
Carpus and Tarsus
- Size of Dog – < 20kg / Dose to be administered – 0.25 – 0.5 mL
- Size of Dog – > 20kg / Dose to be administered – 0.5 – 1 mL
- Size of Dog – All patients / Dose to be administered – 0.01 – 0.1 mL
A single injection of the above-advised volume is considered adequate administration to achieve the effect. Concurrent treatment of multiple joints can be performed.
Mode of action – not all polyacrylamide hydrogels are the same
Polyacrylamide hydrogel products, although often considered equal, have clear differences in composition, manufacturing quality and injection techniques as well as their ability to interact with surrounding tissues. These characteristics determine the safety and effectiveness of each hydrogel.
Upon injection into joints, Synamid®, a uniquely cross-linked 2.5% polyacrylamide hydrogel, adheres to the synovial lining through its ability to exchange water molecules. Over a period of 14 days, the gel becomes integrated into the synovial lining and its immediate surrounding tissue of the inner capsule by a combination of cell migration and vessel ingrowth forming a thick, cushion-like membrane consisting of vessel integrated gel covered by a new and hypercellular synovial cell lining.
Unlike other hydrogels, Synamid® becomes fully integrated into the surrounding tissue (rather than encapsulated) and is therefore long-lasting. Synamid® does not elicit a foreign body reaction or harbour infection. Synamid® is non-pyrogenic, neuro innocuous and contains no heavy metals.
Synamid® is indicated for the management of non-infectious causes of joint disease in dogs, including both early and late stages of osteoarthritis and degenerative joint disease.
Medical history records addressing ongoing infections, concomitant medication, surgery etc. must be reviewed before injection to prevent possible infections.
A cold pack can be applied to the injection site in case of oedema. Local or systemic corticosteroids should not be administered to the animal within two weeks of injection of Synamid® since this may mask a possible infection.
The animal should be rested for 48 hours after treatment and then be on a restricted exercise schedule for 4 weeks post-injection. After this period, the animal should gradually return to normal exercise levels.
Some animals can develop pain within the first few hours post-administration. In addition, there is also a slight risk of haematoma and mild oedema at the site of injection. Within 1-2 weeks after treatment, there is a slight risk that the animal may develop transient oedema and tenderness at the treatment site as the tissue integration is occurring. If not caused by infection, these reactions are self-limiting and will resolve within a couple of weeks. Non-steroidal anti-inflammatory drugs (NSAIDs) can be administered for pain relief and to reduce swelling.
Allergic reactions to Synamid® have not been observed.
Information to the owner
The owner of the animal should be informed about the indications, expected results, contraindications, precautions, warnings and potential complications. The owner of the animal should be advised that in case of complications, the veterinarian who performed the Synamid® injections should be contacted immediately for necessary treatment.
Synamid® must be stored protected from direct sunlight. Do not freeze. Do not store unsealed syringes for later use.
Information For Use (IFU)
Please click on the link below to download the Synamid® Information For Use document.
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